Question
1B. (ii) A genetic engineering lab seeks to determine how well their new CRISPR-Cas9 procedure works when editing lymphocyte cells to remove CLL risk-associated mutations.
1B. (ii) A genetic engineering lab seeks to determine how well their new CRISPR-Cas9 procedure works when editing lymphocyte cells to remove CLL risk-associated mutations. They aim to target 16 of the 45 identified mutations that are present in a lymphocyte cell. In previous trials, they found that their genome editing procedure could successfully edit a single mutation 90% of the time in a single cell. Based on this, estimate the probability that they can successfully edit all 16 target mutations in every one out of 100 lymphocyte cells. 1B. (iii) Based on your calculations above, what is the probability that all 16 target mutations are edited successfully in at least one of 100 lymphocyte cells? 1B. (iv) Do you think that the success rate you calculated would make this method a useful therapy for people at risk for CLL? State Yes or No and explain in one sentence.
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