1)Infectious Disease The degree of clinical agreement among physicians on the presence or absence of generalized lymphadenopathy was assessed in 32 randomly selected participants from a prospective study of male sexual contacts of men with acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition (ARC) [8]. The total number of palpable lymphnodes was assessed by each of three physicians. Results from two of the three physicians are presented in the attached Minitab file.

a.What is the appropriate test procedure to determine whether there is a systematic difference between the assessments of Doctor A vs. Doctor B?

b.Should a one-sided or a two-sided test be performed? Why?

c.Perform the test in part b, and report a p-value.

d.Compute a 95% CI for the true mean difference between observers. How does it relate to your answer to Part c?

was assessed in 32 randomly selected participants from a prospective study of male sexual contacts of men with acquired immunodeficiency syndrome (AIDS) or an AIDS-related condition (ARC) [8]. The total number of palpable lymph nodes was assessed by each of three physicians. Results from two of the three physicians are presented in Table 8.15. 8.39 What is the appropriate test procedure to determine whether there is a systematic difference between the as- Bessments of Doctor A vs. Doctor B? TABLE 8.15 Reproduciblety of assessment of number of palpable lymph nodes among sexual contacts of AIDS or ARC patients Number of palpable lymph nodes Patient Doctor A Doctor B Difference 17 3 11 10 11 12 13 14 15 16 17 18 19 20 21 22 3 23 12 24 25 13 26 12 27 6 2B 29 B 30 15 31 6 32 Mean 7.91 5.16 2.75 80 4.35 3.93 2.83 n 32 32 32