2 1 point What would be the most likely outcome if the MDM2 ubiquitination site on p53 was mutated? (i.e. MDM2 is unable to ubiquitinate p53) Cells would be unable to respond to DNA damage and divide uncontrollably, because p53 operates in the DNA damage response. Cells would divide uncontrollably, because p53 binds to and inhibits E2F, a transcription factor that regulates the restriction point. Cells would arrest because stabilized p53 binds to cyclin-CDK complexes and inhibits them. Cells would arrest because stabilized p53 would drive expression of p21, which binds to cyclin-CDK complexes. No effect; p53 is not ubiquitinated by MDM2. Clear my selection