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2. A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30 g penicillin disks. Each laboratory tested 3 standard strains

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2. A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30 g penicillin disks. Each laboratory tested 3 standard strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on each of the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in the table. Show your whole solution. Mean zone diameters with 30- g penicillin disks tested in 9 separate laboratories Type of control strains S. aureus E. coli P. aeroginosa Laboratorie Different Common Different Common Different Common S medium medium medium medium medium medium A 27.5 23.8 25.4 23.9 20.1 16.7 B 24.6 21.1 24.8 24.2 18.4 17 C 25.3 25.4 24.6 25 16.8 17.1 D 28.7 25.4 29.8 26.7 21.7 18.2 E 23 24.8 27.5 25.3 20.1 16.7 F 26.8 25.7 28.1 25.2 20.3 19.2 G 24.7 26.8 31.2 27.1 22.8 18.8 H 24.3 26.2 24.3 26.5 19.9 18.1 I 24.9 26.3 25.4 25.1 19.3 19.2 a. Provide a point estimate and interval estimate (95% Confidence Interval) for the mean zone diameter across laboratories for each type of control strain, if each laboratory uses different media to perform the susceptibility tests. b. Do the same point estimate and interval estimate at 95% CI for the common medium used. c. Provide a point estimate and interval estimate ( 99% Confidence Interval) for the mean zone diameter across laboratories for each type of control strain, (a) if each laboratory uses different media to perform the susceptibility tests, (b) if each laboratory uses common medium. d. Provide a point estimate and interval estimate (95% Confidence Interval) for the mean zone diameter across laboratories for each type of control strain, regardless of the medium used. e. Are there advantages to using a common medium versus using different media for performing the susceptibility tests with regards to standardization of results across laboratories

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