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(2) Ent-Kaurene is an important (diterpene) biosynthetic intermediate in making many bio- active agents, including plant hormones such as gibberellins. Indicate the isoprene units

(2) Ent-Kaurene is an important (diterpene) biosynthetic intermediate in making many bio- active agents, including plant hormones such as gibberellins. Indicate the isoprene units in ent-kaurene. Note the biosynthetic pathway for this diterpene shown starting from geranyl-geranyl pyrophosphate (GGPP) shown below1: I expect you to identify the "correct" isoprene units (based on the biosynthetic pathway) and not just any head-to- tail linked isoprene units. As a guide, I have numbered several carbons in the ent- kaurene (and in the ent-CPP intermediate) structure based on the IUPAC numbering of GGPP. 17 17 19 19 P OPP 19 17 18 18 CPS KS 16 16 20 "ent-CPP ent-kaurene 20 GGPP 20

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