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2. Hemodialysis is a treatment for kidney failure that rids the body of unwanted toxins. Blood and dialysis fluid enter a hemodialyzer in a concurrent
2. Hemodialysis is a treatment for kidney failure that rids the body of unwanted toxins. Blood and dialysis fluid enter a hemodialyzer in a concurrent fashion as illustrated in the figure below. One way we can model this process is by assuming the blood and dialysis compartments can each be modelled as well-mixed compartments. The barrier between the compartments has a permeability-surface area of PS and the partition coefficient for the toxin between the blood and dialysis fluid is . a. Determine the set of differential equations that can be used to describe the concentration of the toxin in the blood leaving the hemodialyzer, CbL. b. Solve by hand for the concentration of the toxin in the blood leaving the hemodialyzer at steady state. c. Solve using MATLAB for the concentration of the toxin in the blood leaving the hemodialyzer at steady state. For parts D and E:Qb=1ml/min,Qd=1ml/min,Cdo=0, and Cbo=10mg/ml d. Examining the influence of permeability: If the partition coefficient from blood to dialysis fluid is 0.5 , compare the reduction in toxin concentration in the blood (CbL/Cbo) when PS =0.3mL/min versus PS=0.7mL/min. What does this tell you about the role of the barrier permeability and how would this influence your design of a hemodialysis device? e. Examining the influence of the partition coefficient: If PS=2mL/min, compare the reduction in toxin concentration in the blood (CbL/Cbo) when the partition coefficient from blood to dialysis fluid is 0.2 compared to 1.5 . What does this tell you about the role of the partition coefficient and how would this influence your design of a hemodialysis device
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