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2. In a study investigating the relationship between exercise and risk of coronary heart disease (CHD) among women, a cohort of healthy women (assume no
2. In a study investigating the relationship between exercise and risk of coronary heart disease (CHD) among women, a cohort of healthy women (assume no CHD at the beginning of the study) aged 35-60 were surveyed to ascertain the frequency of weekly exercise. The women were followed for 10 years. Investigators observed a total of 134 incident cases of CHD, 80 among women that reported exercising once per week, 21 among women that reported exercising twice per week, and the remainder in the group that reported no regular exercise over the study period. Person-years of observations for the exposure groups were as follows: 87,082 p-yrs for twice per week, 198,003 p-yrs for once per week, and 65,329 p-yrs for no exercise. - a. Set u the 2 x 3 table for anal sis of this data. No Exercise Exercise Once Per Exercise Twice Per Week Week Yes CHD "El 65 329 198 003 87 082 b. Calculate the most appropriate measure of disease frequency for the exposure groups. Note: multiply by 10,000 so numbers are meaningful. Incidence Rate (134/lggggg; Z !*10000= 3.82% c. Calculate the most appropriate measure of association and 95% condence interval using no exercise as the referent group. d. Assuming causality, how many excess CHD cases per 10,000 person-years can be attributed to the effect of no exercise in each of the other exposure groups? e. Assuming causality, what proportion of the CHD cases among women that exercised once per week or twice per week were prevented by exercise. Calculate the measures separately
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