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2 In an experiment, the effects of xenobiotic activation of the compound benzo[a]pyrene, a chemical carcinogen present incigarette smoke, are studied in various tissues.
2 In an experiment, the effects of xenobiotic activation of the compound benzo[a]pyrene, a chemical carcinogen present incigarette smoke, are studied in various tissues. Investigators determine that formation of a secondary metabolite, which binds covalently to DNA, increases the frequency of lung cancers. Which of the following is the most likely metabolic pathway for generation of this xenobiotic? (A) Biomethylation (B) Cytochrome P-450 (C) Flavin-containing monooxygenase (D) Glucuronidation (E) Glutathione (F) Peroxidase-dependent cooxidation
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Human Biology
Authors: Sylvia S. Marder, Michael Windelspecht
13th edition
73525480, 978-0073525488
