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3. A clinical trial was conducted in which 50 patients were randomly assigned to one of five cholesterol -reducing drug regimens . Three of the
3. A clinical trial was conducted in which 50 patients were randomly assigned to one of five cholesterol -reducing drug regimens . Three of the drug regimens involved the same drug administered as 20 mg once per day (1time ), 10 mg twice per day (2times ), or 5 mg four times per day (4times ). The two remaining drug regimens (drugD and drugE ) represented competing drugs . Previous studies have shown that cholesterol reduction is approximately normally distributed with equal variance across patients receiving a range of different cholesterol -reducing drugs . The data set for the trial is in the Data folder in A2L Contents , is called Q3_CHOL , and has two variables : trt (indicating drug regimen ) and response (indicating cholesterol reduction in mmol /1). Use these data to answer the questions below. Assume a=0.05 . a. Create a box & whisker plot to compare the cholesterol reduction levels across the five treatment groups. Comment on the pattern you see in cholesterol reduction across the treatment groups. [2 Marks ] b. Run the appropriate statistical test to determine if there is a significant difference in the cholesterol reduction levels across the five treatment groups. What do you conclude from running this test? Provide the calculation and/or SPSS output to support your answer. [1
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