#4

4. A pharmacokinetic study of a particular drug taken orally as a single dose provided an AUC of 1085.5 og hr/mL, a Spax equal to 98.5 pg/ml, and a Tmax of 2.1 hr. The drug dose was 80 mg and the drug does not bind to proteins (i.e., f = 1). From the given data, determine (A) the apparent volume, (B) the elimination rate constant (kte), and (C) the absorption rate constant (ka). Plot the concentration profile over a 24-hr period. (Ans: kte = 1.2484 hr-1; ka = 0.1157 hr-1)