5-8 are all together

9-11 are all together

Questions 9 through 11 You are provided with three plots depicting the parameters on the y-axis and x-ads. For each plot, draw the graph based on the information provided. 9. A plot of Plasma Concentration (y-axis) vs time (x-axis) after IV bolus administration for a medication that displays "one-compartment model pharmacokinetic behavior. Concentration Time 10. A plot of Elimination Rate (y-axis) vs time (x-axis) after IV bolus administration for a medication that displays that displays linear pharmacokinetics dx/dt Concentration 11. A plot of in Plasma Concentration (w-axis) vs time (x-oxis) after IV bolus administration for a medication that displays "two-compartment model pharmacokinetic behavior. in (Concentration) Time Questions 12 through 15 12. An IV bolus dose of a drug produces an initial plasma concentration of 40 mg/L. Twelve hours later, the plasma concentration declines to 5 mg/L. What is the elimination t1/2 of this drug? 13. Briefly explain the difference between 'one-compartment model pharmacokinetics and two-compartment model pharmacokinetics. 14. DRUG A is administered as a single IV bolus dose (1 mg/Kg) to a 65 year old male patient (75Kg). The drug follows one compartment pharmacokinetics and has an elimination rate constant of 0.116 hr!. The apparent volume of distribution is 269L. What is the predicted plasma concentration of DRUG A six hours after the dose was administered to this patient? 5. A patient (60 kg) receives an IV bolus dose of DRUG P (1 mg/kg). Two plasma samples are taken from the patient at 2 hr and 12 hr post-dose. The plasma concentration of DRUG P in these samples was 126 ng/ml and 32 ng/ml, respectively. What is the elimination rate constant for DRUG P? UD When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/ml) observed over time (hr) can be described by the following equation C = 3.6e-0.1056 C=3.66 0.105 5. Calculate AUC(0-) AUCO- 3.6 l 0-105 = 34.28 DOSE V=27.8 Vo Co 6. What is the volume of distribution? 100 = 27. 3.6 7. Calculate the clearance of this drug. C1=kXVD Cl = 0.1058 27.8 C1=2.91 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL