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6. A patient who took a severe overdose of aspirin (acetylsalicylic acid) was admitted to the hospital 2 hours after her overdose. The questions below
6. A patient who took a severe overdose of aspirin (acetylsalicylic acid) was admitted to the hospital 2 hours after her overdose. The questions below refer to her case. a) After admission to the hospital, the patient's respiratory rate increased (hyperventilation, caused by the overdose). After several hours, her blood pH rose to 7.55, outside of the normal range of 7.35-7.45. The blood is buffered by the bicarbonate system, which can be described by the equations below and is discussed in the reading. Explain how the overdose-induced hyperventilation resulted in an increase in blood pH. CO, (g) Co, (dissolved) CO, (dissolved) + HO H.CO HACO + H+ HCO, OH b) The patient's condition continued to worsen for 10 hours. The doctors worried that this could be due to accretions of undissolved acetylsalicylic acid had formed in the stomach. Acetylsalicylic acid has a pk, of 3. Gastric lavage was performed with a pH 8.5 solution i) Calculate the percentage of protonated and deprotonated forms of acetylsalicylic acid at the pH of the stomach, which is usually around 2. acetilsalicylic acid li) Calculate the percentage of protonated and deprotonated forms of acetylsalicylic acid at pH 8.5 water. Explain why. Why did the treatment result iii) Acetylsalicylic acid is only slightly soluble in increased solubility of the drug
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