6-Aminopenicillanic acid used to produce semi-synthetic penicillins is prepared by enzymatic hydrolysis of fermentation-derived penicillin G. Penicillin acylase immobilised in alginate is being considered for the process; the immobilised-enzyme particles are small enough that mass-transfer effects can be ignored. The starting concentration of penicillin G is 10% (w/v); because of the high cost of the substrate, 99% conversion is required. Under these conditions, enzymatic conversion of penicillin G can be considered a first-order reaction. It has not been decided whether a batch or CSTR. The downtime between batch reactions is expected to be 20 h. For the batch and CSTR reactors, the reaction rate constant is 0.8 x10-4 s-1 Determine the smallest reactor required to treat 100 tonnes penicillin G per year