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(8) Suppose the number of patients participating in a study is n(which is the number of trials), and the number of patients who response to

(8) Suppose the number of patients participating in a study is "n"(which is the number of trials), and the number of patients who response to the therapy is "X" (which is the number of successes), the sample proportion =

(9)If the sample proportion is nearly normally distributed, ________________approximation to Binomial can be used to conduct the inference.

(10) __________________ inference based on the Binomial Distribution is used when X does not havean approximately normal distribution.

(11)What are the two conditions for the sampling distribution of being nearly normal?

(12) If the two conditions are met, then the sampling distribution of is approximately normal with mean p and standard error determined by what formula?(note: standard error is another name for the standard deviation of the sampling distribution ofP)

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