A 28-year-old male was found unconscious in a bathtub full of ice by his roommate who took him to an emergency department. On admission, he was conscious but confused and hyperthermic with some muscle rigidity. He thought he had gotten food poisoning, but the symptoms have gotten progressively worse. His roommate reminds him that he also has been taking some body-building supplements ordered from the internet. Toxicology reports were negative for alcohol and positive for 2,4-dinitrophenol, later confirmed to be from the supplements.

1. Based on this information, please summarize this individual’s metabolic state at the time of presentation. - Be sure to include: o Rates of oxygen consumption o ATP production o Levels of mitochondrial NADH o An explanation for the increase in body temperature.

2. Discuss 2,4-dinitrophenol and how it impacts metabolism