A 55-year-old woman has had discomfort and swelling of the left leg for the past week. On physical examination, the leg is slightly difficult to move, but on palpation, there is no pain. A venogram shows thrombosis of deep left leg veins. Which of the following mechanisms is most likely to cause this condition?

(A) Turbulent blood flow

(B) Nitric oxide release

(C) Ingestion of aspirin

(D) Hypercalcemia

(E) Immobilization