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(a) Consider a rock climber at elevation of 14,000ft(4300m ). At this elevation, Hemoglobin has a P50=28mmHg and a Hill coefficient = 3.2. Calculate the
(a) Consider a rock climber at elevation of 14,000ft(4300m ). At this elevation, Hemoglobin has a P50=28mmHg and a Hill coefficient = 3.2. Calculate the change in Fractional O2 Saturation of the climber's hemoglobin going from the lungs (where Po2= 48mmHg ) to the muscletissue (where Po2=17mmHg )? Draw the oxygen binding curve for the climber's hemoglobin. Indicate the range of the y-axis. Label the P50 And the P02 In both the lungs and tissue. Indicate Y02 between The lungs and tissue. ) Now consider that the climber has a genetic mutation that reduces the Hill coefficient to 1.3 And the P50=16mmHg. Sketch the new oxygen binding curve on the graph above. (Clearly indicate which protein is which). Assuming the same concentrations of Oxygen In the Lungs and tissue, how does Yo2 In the mutated Hb compare to the wild-type Hb
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