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A critical parameter in the design of bioreactors is the maximum shear stress experienced by cells while in the reactor. If the shear stress is
A critical parameter in the design of bioreactors is the maximum shear
stress experienced by cells while in the reactor. If the shear stress is too high, the cells
will be torn apart or lysed. An example of a common biomedical device in which the
shear stress must be controlled is a blood oxygenator used clinically for heartlung bypass
operations. Hemolysis can occur if red blood cells adhere to the wall of the device and
are subjected to high shear stresses.
Consider a blood oxygenator in which steady laminar flow of blood is directed through a
parallel membrane separated by a distance of What is the shear stress at the membrane
surface in terms of the average flow velocity, V Assume that the blood is a Newtonian
fluid with viscosity and that the semipermeable membranes can be modeled as infinite
planes. The geometry is depicted below:
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