Question
a. Lamivudine 1 is an inhibitor of HIV reverse transcriptase and is used to combat HIV. i. Apply Lipinskis Rules to the structure of lamivudine.
a. Lamivudine 1 is an inhibitor of HIV reverse transcriptase and is used to combat HIV.
i. Apply Lipinski’s Rules to the structure of lamivudine.
ii. What does your Lipinski analysis tell you about the suitability of lamivudine as a drug? What are the limitations of this analysis?
iii. By comparing the structure of lamivudine 1 to cytosine deoxyribonucleotide 2, explain briefly how this drug might inhibit reverse transcriptase, and how doing so can fight HIV/ AIDS.
NH2 NH2 N. HO HO S HO Lamivudine 1 Cytosine deoxyribonucleotide 2 Molecular Weight: 229.25 LogP: -1.4
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1 As we know HIV is virus responsible for autoimmune disorder AIDS HIV means in human immunodeficiency virus HIV while AIDS is stand for acquired immunodeficiency syndrome Now we discuss as per ask in ...
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Biochemistry Concepts and Connections
Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews
1st edition
321839927, 978-0133853490, 133853497, 978-0321839923
