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A matched case-control that included 1,530 study participants was conducted to investigate the association between polycystic ovary syndrome (PCOS, exposure) and severe anxiety (Beck Anxiety
A matched case-control that included 1,530 study participants was conducted to investigate the association between polycystic ovary syndrome (PCOS, exposure) and severe anxiety (Beck Anxiety Inventory (BAI) score between 30 and 63) among women of reproductive age. Matching was done based on frequency matching of two possible confounding variables: age group (+/- 3 years) and body mass index (BMI) categories (normal, overweight, and obese). The results for the 1,000 pairs are shown below. Controls PCOS (+) Exposed PCOS (-) Not Exposed Cases Exposed (+) 243 353 Not Exposed (-) 245 159 If the investigators had decided to conduct a traditional case-control study, in which no matching was applied, what would be the appropriate measure of association [part A]? Let's assume the calculated OR and its 95% CI from Q1 were the results of the traditional case-control study. Please provide a complete interpretation of the proper measure of association and 95% of CI for the traditional case-control study design [part B]
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