Question: A mutation that changes an alanine residue in the interior of a protein to valine (A157V157) is found to lead to a loss of proper

A mutation that changes an alanine residue in the interior of

A mutation that changes an alanine residue in the interior of a protein to valine (A157V157) is found to lead to a loss of proper folding and activity. However, proper folding and activity are regained when a second mutation at a different position changes a leucine residue to glycine (L185G185). Based on these observations, you hypothesize that amino acid residues 157 and 185 are spatially close to each other in the folded and active protein. How does your hypothesis explain the data, that the double mutant (A157V157;L185G185) has activity that the single mutant (A157V157) lacks

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