A new drug is being pilot-tested for treatment of apnea (a transient cessation of breathing) in premature infants. The outcome of interest is the average number of apneic episodes per hour and was measured before and after drug treatment (an average was taken over several hours for each infant).

Investigators would like to know whether the new drug has any effect on the average number of hourly episodes. Which test is most appropriate?

Frequency Frequency 1 2 4 .0 "Episodeshour 24 hours before treatment Difference in episodes hour (before afood Frequency Episodes hour no hound itter wantme2"