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A nicotine-patch 2 cm (length) x 2 cm wide x 2 cm depth is being designed to enable cessation from smoking TO.the diffusion coefficient of

A nicotine-patch 2 cm (length) x 2 cm wide x 2 cm depth is being designed to enable cessation from smoking TO.the diffusion coefficient of nicotine is 10^-7 cm^2/s., ending 1 mm deep from the skin surface, during unsteady state, the full penetration depth for a given time is when the erf=1. this occurs when n=3. After 100 seconds when the nicotine patch was first placed on the skin, what is the ratio of steady state flux to unsteady state flux at the nerve ending 1mm away?

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