A pharmaceutical company develops two new drugs, Drug A and Drug B, to prevent a second myocardial infarction (MI) in subjects with past history of single MI. Subjects with past history of single MI are randomized into one of three groups: Drug A, Drug B, and standard of care and it is determined after one year if they experienced a second MI (yes/no). Which test is most appropriate to determine if there are differences in the occurrence of a second MI event between the groups?

Question options:

a. two-sample t-test

b. ANOVA

c. paired t-test

d. Chi-squared test