Question
A prospective cohort study was conducted to determine if there binge drinking during pregnancy increases the risk a SIDS in infants. The results are shown
A prospective cohort study was conducted to determine if there binge drinking during pregnancy increases the risk a SIDS in infants. The results are shown below:
SIDS | ||||
Yes | No | |||
Binge Drinking | Yes | 45 | 300 | 345 |
No | 155 | 9,500 | 9,655 | |
200 | 9,800 | 10,000 |
1. Calculate the crude relative risk for this association and provide an interpretation.
2. You now wish to assess for effect modification by maternal age (defined as mothers 21 and under and mothers over 21. Using the tables below, calculate the stratum specific measures of association and provide an interpretation of your estimates.
Table 2. Comparison of binge drinking during the 1st trimester of pregnancy and SIDS cases among mothers aged 21 and under.
SIDS | Healthy | |
Binge Drinking During the 1st Trimester among Mothers 21 and Under | 20 | 55 |
No Binge Drinking among Mothers 21 and Under | 100 | 4,500 |
Table F3. Comparison of binge drinking during the 1st trimester of pregnancy and SIDS cases among mothers aged over 21.
SIDS | Healthy | |
Binge Drinking During the 1st Trimester among Mothers Over 21 | 25 | 100 |
No Binge Drinking among Mothers Over 21 | 200 | 5,000 |
3. Use and online calculator to conduct the Breslow's Day Test for Homogeneity. Write the null and alternative hypotheses. What is your conclusion is maternal age an effect modifier?
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