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A prospective cohort study was conducted to determine if there binge drinking during pregnancy increases the risk a SIDS in infants. The results are shown

A prospective cohort study was conducted to determine if there binge drinking during pregnancy increases the risk a SIDS in infants. The results are shown below:

SIDS
Yes No
Binge Drinking Yes 45 300 345
No 155 9,500 9,655
200 9,800 10,000

1. Calculate the crude relative risk for this association and provide an interpretation.

2. You now wish to assess for effect modification by maternal age (defined as mothers 21 and under and mothers over 21. Using the tables below, calculate the stratum specific measures of association and provide an interpretation of your estimates.

Table 2. Comparison of binge drinking during the 1st trimester of pregnancy and SIDS cases among mothers aged 21 and under.

SIDS Healthy
Binge Drinking During the 1st Trimester among Mothers 21 and Under 20 55
No Binge Drinking among Mothers 21 and Under 100 4,500

Table F3. Comparison of binge drinking during the 1st trimester of pregnancy and SIDS cases among mothers aged over 21.

SIDS Healthy
Binge Drinking During the 1st Trimester among Mothers Over 21 25 100
No Binge Drinking among Mothers Over 21 200 5,000

3. Use and online calculator to conduct the Breslow's Day Test for Homogeneity. Write the null and alternative hypotheses. What is your conclusion is maternal age an effect modifier?

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