Question
A protein molecule of human serum albumin in a physiological solution undergoes a denaturation transition with the increase in temperature. The transition happens around 70
A protein molecule of human serum albumin in a physiological solution undergoes a denaturation transition with the increase in temperature. The transition happens around 70 degrees Celsius in a narrow temperature range about 1 degrees celcius. The transition is from a compact native state with approximately 10^10 microstates(due to excited vibrational modes) to a more open denaturated state with approximately 10^100 microstates(due to rotation of about 50 side groups).
Find the amount of heat transfer involved in the denaturation. Is the heat absorbed or rejected by the protein molecule?
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Quantitative Chemical Analysis
Authors: Daniel C. Harris
9th Edition
146413538X, 978-1464135385
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