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(a) The first step of cyclization of conversion of GTP to c-di-GMP, a biological signaling molecule, is catalyzed by an aspartate and produces the intermediate,

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(a) The first step of cyclization of conversion of GTP to c-di-GMP, a biological signaling molecule, is catalyzed by an aspartate and produces the intermediate, pppGPG, as shown below. Draw a mechanism to describe the electron flow for this first reaction in the cyclization. 0.00 OH OH ofototoy Asp O. + PPI ofoto 0-40 o- Oo G OH OH OH OH NH G- NH (b) If we added inorganic pyrophosphatase, which catalyzes the hydrolysis of PP, to 2P, to this reaction, what effect might this enzyme's activity have on the synthesis on pppGpG

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