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A transdermal patch is designed to deliver Methadone. Before the drug is delivered across the skin, it diffuses through a rate - controlling membrane between

A transdermal patch is designed to deliver Methadone. Before the drug is delivered across the skin, it diffuses through a rate-controlling membrane between the drug reservoir and skin. The surface area, thickness, diffusion coefficient, and partition coefficient K (Oil/Water) of the membrane is 10 cm2,100\mu m,10-8 cm2 sec-1 and 10, respectively. Calculate the permeability coefficient of this drug through this membrane.

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