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a) Why is the formation of a-ketoglutarate strongly regulated? b) Pyruvate kinase is inhibited by ATP, Ala and acetyl CoA, and is activated by AMP

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a) Why is the formation of a-ketoglutarate strongly regulated? b) Pyruvate kinase is inhibited by ATP, Ala and acetyl CoA, and is activated by AMP and fructose-1,6- bisphosphate. Assuming for a moment that not all of the allosteric effectors were known for this enzyme, propose one additional activator and one additional inhibitor. Justify the logic of your

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