Accounting innovation and change has received the increased attention of accounting historians. Coupled with the recognition of the historical contingency of accounting practices, these studies serve to underscore the contingent relationship of accounting with a variety of environmental factors. The current case study examines this relationship within one nineteenth-century Canadian firm,specifically the introduction of management accounting information.

Question 12 Can anaemia be a differentiating point between muscle wasting and cachexia owing to another systemic disorder?

Question 13 Anaemia of chronic disease does not respond to iron therapy, but there are trials studying the use of iron and erythropoietin (EPO). Could you tell me where to find more detailed information about these trials, and whether there have since been any further developments?

Question 14 Is the deoxyuridine test helpful?

Question 15 The Schilling test is very rarely performed. Why is this?

Question 16 There is no extramedullary haematopoiesis in aplastic anaemia, why?

Question 17 Why is the anaemia in aplastic anaemia, macrocytic?

Question 18 Is vitamin B12 absorbed passively from the jejunum?

Question 19 What role does 'R' binder play in the absorption of vitamin B12?

Question 20 In pernicious anaemia, investigation of the serum shows an elevated level of gastrin. Why is it so? Haematological disease 8 67

Question 21 1. Please explain the term Coombs' positive (direct and indirect) and negative haemolytic anaemia. 2. What are the principles of the Coombs' test?