2. Addison's Disease: chronic adrenal deficiency most commonly caused by an autoim mune disorder that destroys the adrenal cortex. How would this disorder affect levels of CRH. ACTH, cortisol, and aldosterone? Draw out the H-P-A pathway to illustrate the se changes. 3. Congenital Adrenal Hyperplasia (CAH): class of genetic disorders caused by deficiency in enzymes responsible for production of cortisol. How would this condition affect levels of CRH ACTH, cortisol? Why does it lead to adrenal overg rowth? Draw pathway Adrenal pathologies 1.Cushing Syndrome: when there is too much cortisol in the body. (i) Exogenous Cushing syndrome results from high intake of cortisol from outside sources (medications such as prednisone), which are used in the treatment of conditions like rheumatoid arthritis, lupus, IBD, and MS. (ii) Endogenous Cushing syndrome results from an adrenal gland or pituitary gland tumor. SYMPTOMS of Cushing's syndrome How would these disorders affect levels of CRH, ACTH, cortisol? Draw out the H-P-A pathway to illustrate these changes. glands Adrenal CNS irritability Emotional disturbances Red and round face Cushing syndrome from medication: CRH H Hypertension cortisol (made by patient's body)_ Excess cortisol Cardiac hypertrophy cortisol (from medication) Obesity (fat deposition on abdomen and back of neck) Hyperplasia, tumor Purple striae Cushing syndrome from adrenal tumor: CRH ACTH cortisol Osteoporosis Muscle wasting Skin ulcers Cushing syndrome from pituitary tumor: CRH H cortisol In females: - amenorrhea, hirsutism In males: erectile dysfunction