Adult onset diabetes, diabetes type 2, can best be describe dusing which of the following concepts?

A. Constantly high blood sugar leads to high insulin release.High levels of insulin cause up-regulation of insulin receptors. 

B. Constantly high blood sugar leads to high insulin release.High amounts of insulin to down-regulation of insulin receptors.

C. Constantly high blood sugar leads to glucagon release.Glucagon is an antagonist to insulin, leading to a decrease ininsulin. 

D. Constantly high blood sugar leads to the release of glucagon.Glucagon causes gluconeogenesis, which makes blood sugarhigher.