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All reactions indicated by each arrow are elementary reactions, and ks indicated are reaction rate constants for each reaction. ES1 and ES2 are different types

All reactions indicated by each arrow are elementary reactions, and ks indicated are reaction rate constants for each reaction. ES1 and ES2 are different types of reaction intermediates. Both equilibrium reactions reach equilibrium at a very high rate and the fast equilibrium appr assumes that the reaction in which the last P is produced is relatively slow.
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S+Ek2k1ES1k4k3ES2kcatE+p S+Ek2k1ES1k4k3ES2kcatE+p

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