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1. Alora is a transdermal system designed to deliver estradiol continuously and consistently over a 3-4 day period when placed on the skin. Alora provides systemic estrogen replacement theory in postmenopausal women. For a 36 cm patch, the release rate of the drug is 0.1 mg of estradiol per d ay. Clinical trials have provided the following pharmacokinetic data. In one study, following applications of the patch, the peak concentration of the estradiol was found to be 144 pg mL (1012 pg = 1 g) and the half life of estradiol was found to be 1 h. Over an 84 h dosing interval, the plasma clearance for estradiol from the Alora patch was found to be 61 L h!. What is the apparent volume of distribution in liters?