Amino acid side chains act as nucleophiles and proton donor$/$acceptors in various enzymatic reactions. We will use them frequently in reactions during $40B$ and therefore the purpose of this exercise is to review the properties of amino acid side chains you have learned in $40A.$

Ozempic is a medication used for the treatment of type $2$ diabetes and an anti$-$obesity treatment. Ozempic is a modified peptide that mimics the structure of the natural hormone GLP$-1.$

Fal$-$Arg Cly Ang Chy$-$OM

a$.$ Add above the tree$-$letter code of each amino acid the relevant functional group on its side chain.

For example: $-$ Ser$-$ will be represented by $I^{O}H.$

b$.$ The protonation state of each functional group depends on the $pH$ of the solution. Assume that Ozempic is in a solution at $pH=7.$ Draw the functional groups at their correct protonation form.

c$.$ What will be the protonation state of the long non$-$peptide side chain at $pH=7?$