An experimental drug is administered in the following manner: 100 mg q12h. Calculate the extraction ratio in an 80 kg patient, given the following information: liver blood flow is 1.5 L/min; t1/2 = 50 h; Vd = 0.1 L/kg; no non-hepatic elimination; fu = 0.1.

What is the Css?

What is the unbound Css?

Predict what happens to steady-state concentrations if the unbound concentration doubled as a result of a drug interaction.

Predict what happens to unbound steady-state concentrations as a result of the drug interaction?

Predict what happens to clearance as a result of the drug interaction.

If another CYP inducer increased CL by 50%, what happens to Css and unbound Css.

If hepatic blood flow was reduced from 1.5 L/min to 1 L/min, predict what would happen to CL, steady-state concentrations and unbound steady-state concentrations.