an explanation of All procedures were conducted with the approval of Afyon Kocatepe University (AKU) Animal Ethics Committee (reference number 9016). A total of 48 male Wistar Albino rats weighing 180-290 g, 5-6 months old, were used in the present study. Experimentally hypothyroidism (Moulakakis et al., 2008) and hyperthyroidism (Subudhi et al., 2008) were performed in eight groups, two control and six experimental groups, with six rats in each group as follows: groups with hypothyroidism (HT), ( 1) control: rats were fed a standart diet and given 1 ml 0.9% saline by gastric gavage; ( 2) HT: rats were given added to daily drinking water 0.05% PTU (Sigma, P3755); ( 3) NSE: given 200 mg/kg NSE, body weight (BW)/day, gastric gavage; and ( 4) HT + NSE: rats were given added to daily drinking water 0.05% PTU + 200 mg/kg BW, NSE/day, gastric gavage; groups with hyperthyroidism (HP), ( 1) control: rats were fed a standart diet and given 1 ml 0.9% saline by gastric gavage; ( 2) HP: rats were given added to daily drinking water 0.0012% LT4 (Sigma, T2376); ( 3) NSE: given 200 mg/kg NSE, BW, /day, gastric gavage; and ( 4) HP + NSE: rats were