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An investigator, performing an animal study designed to evaluate the effects of vegetable and vegetable-fiber diets on mammary carcinogen- esis risk, randomly assigned female Sprague-Dawley
An investigator, performing an animal study designed to evaluate the effects of vegetable and vegetable-fiber diets on mammary carcinogen- esis risk, randomly assigned female Sprague-Dawley rats to five dietary groups (control diet, control diet plus vegetable mixture, 1; control diet plus vegetable mixture, 2; control diet plus vegetable-fiber mixture, 1; and control diet plus vegetable-fiber mixture, 2). Mammary tumors were induced by a single oral dose (5 mg dissolved in 1.0 ml. corn oil) of 7,12-dimethylbenz(@)anthracene (DMBA) administered by intragastric intubation, i.e., the starting point for this study is when DMBA was given. Starting 6 weeks after DMBA administration, each rat was examined once weekly for 14 weeks (post DMBA administration) and the time (in days) until onset of the first palpable tumor was recorded. We wish to make an inference about the marginal distribution of the time until a tumor is detected. Describe, in detail, the types of censoring that are represented by the following rats. (a) A rat who had a palpable tumor at the first examination at 6 weeks after intubation with DMBA. (b) A rat that survived the study without having any tumors. (c) A rat which did not have a tumor at week 12 but which had a tumor at week 13 after inturbation with DMBA. (d) A rat which died (without tumor present and death was unrelated to the occurrence of cancer) at day 37 after intubation with DMBA
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