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Analyse the given excel spreadsheet results of first 4 subjects: no subject with expected results (partial response) expected partial response was 30% Question: Should this

Analyse the given excel spreadsheet

results of first 4 subjects: no subject with expected results (partial response)

expected partial response was 30%

Question: Should this company's CEO to stop this clinical trial?

image text in transcribed
MA 2021 H2 210914 Q Home Insert Page Layout Formulas Data Review View LE Share Arial v 10 A A = ab v General Insert x Delete v I v Paste IUV 00 Conditional Format Cell Sort & Find & Formatting as Table Styles Format v D Filter Select Open recovered workbooks? Your recent changes were saved. Do you want to continue working where you left off? Yes No x Subscription Required to Edit and Save Start your free one month trial of Microsoft 365 or sign in to activate an existing subscription. Activate 07 4 X V fx p A B CDEF GHI J K L M N 0 P Q R S T U V w X Binomial distribution B (N, P) N: the number of trials, p: event prob X = the number of H N=3, p=.7 A, T 0.56667 0.4 0.5 0.6 0.5 0.1 0.9 Trial 3 2 Prob (X=0) = 3CO * (1-p) * (1-p) * (1-p) 0.566667 LL -12.8366669332 14.52739 13. 10413 12.90553 -16.1644001908 -34.5541226 34.5541226 1 H H Prob (X=0) = 1 * 0.7 ^ 0* ( 1-0.7) ^3 Prob (X) Likelihood 0.00000266 0.00000 0.00000 .00000 0.000000 0.000000 0.0000000 HII HI H Prob (X=0) 0.027 0.081370372 0.081370372 0.21600 0. 12500 .06400 0.015625 0.5314410 0.0000010 . . . - O G F W N J O O O V O U A W N - 3 H I y Prob (X=1) 0.319222224 0.032529648 0.08062 0.05273 0.02389 0.019775 0.0034868 0.0000005 N A W - Prob (X=2) 0.417444443 0.030366500 0.00688 0.01978 0.03483 0.019775 0.0000005 0.003486 Events H # X=H ; Case # Observed Prob Prob (X=3) 0.181962961 0.033110519 0.00410 0.01563 0.04666 0.015625 0.0000010 0.5314410 0.10 - 0 0.30 Maximum LIKenInood Estimation W N 0.40 0.20 ON O - WN W - - NNN- O

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