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As the amount of physical activity (measured in MET hours/week) increases,the risk of type 2 diabetes decreases. Which one of the criteria for judging causality

As the amount of physical activity (measured in MET hours/week) increases,the risk of type 2 diabetes decreases. Which one of the criteria for judging causality best corresponds to the scenario.

Dose-response
Replication
Consideration of alternate explanations
Biologic plausibility

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