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Aspartic acid has two carboxyl groups and one amide group that can each undergo an acid dissociation (see Table A.3-6 in the book). When solving
Aspartic acid has two carboxyl groups and one amide group that can each undergo an acid dissociation (see Table A.3-6 in the book). When solving this problem, let A2 represent the fully dissociated form of the acid in which both carboxyl groups are in their negatively charged form COOand the amide group is in its uncharged form NH2. Other forms of the acid can be represented by adding H+groups to A2. For example, the zwitterion will can be represented by H2A. (a) Write the sequence of dissociation equations for H3A+,H2A and HAthat progressively occur when an aspartic acid solution initially at a very low pH is titrated with a strong base until it reaches a very high pH. (b) Write the equation relating the concentrations of charged aspartic acid species at the isoelectric point. (c) Let 1,2 and 3 represent the equilibrium constants for the dissociation of H3A+,H2A and HA, respectively. Write the formulas for these dissociation constants in terms of species concentrations. (d) From the results of (b) and (c), derive an equation for CH+at the isoelectric point in terms of the 1,2 and 3. (e) Using the values of pKK1=log1=1.88,pK2=3.65 and pK3=9.6, solve this equation for CH numerically and obtain the value of pH at the isoelectric point
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