Aspirin is the most widely used drug in the world, with more than $100$ billion

tablets consumed annually. The active component, salicylic acid, originally

from willow bark, was used as a folk remedy as long ago as the $5$th century

BC$.$ But it wasn't until $1897$ that German chemist Felix Hoffman managed to

synthesize aspirin in a pure and stable form, making it one of the earliest

synthetic drugs. Aspirin is now taken for a huge variety of afflictions, from

fever and arthritis to the prevention of heart attacks, stroke, and dementia.

The structures of aspirin, salicylic acid, and acetylsalicylate are shown below.

The carbons are not labeled. They occur wherever two black lines intersect.

Two black lines in parallel to each other indicate a double bond. Use these

images to answer the questions $1-4.$

Aspirin

Salicylic Acid

Acetylsalicylate Question $6$

T$/$F: Free energy diagram $F$ cannot represent the conversion of aspirin to

salicyclic acid under cellular conditions.

True

False

Question $7$

If free energy diagram $B$ represents the conversion of aspirin to salicylic acid

under conditions with BChE, which free energy diagram could represent the

conversion of aspirin to salicylic acid under the same conditions, but without

BChE present? Select all that apply.

Graph A

Graph B

Graph C

Graph D

Graph E

cannot be determined