Assume no acid-base catalysis occurs and the following data: 1. The dG of E + TS binding to form E-TS (dGb) is -6.00 kJ/mol 2. The dG of E + S binding to form ES (dGs) is -2.00 kJ/mol. 2. A small weak force mismatch between E and S costs +3 kJ/mol. This is not present when E binds the transition state TS. Assume biological conditions (310K).

What is the dS of enzyme-substrate binding?

Use kJ/(mol*K) and 2 sig figs.