Atorvastatin is a cholesterol lowering drug whose mechanism ofaction is the inhibition of HMG-CoA reductase. If a patient takes a10.0 mg dose of atorvastatin, what is the concentration ofatorvastatin in the blood? Assume the patient has 5.0 L of blood.The molecular weight of atorvastatin is 559

Atorvastatin is a competitive inhibitor of HMG-CoA reductasewith a Ki of 7.5 × 10-3 ?M. What fraction of the enzyme will have abound substrate under the conditions described above? Assume theconcentration of HMG-CoA is 15 ?M, and the KM for HMG-CoA reductaseis 1.4 ?M.

After a period of time, all but 0.10% of the atorvastatin in theblood is metabolized. What fraction of the enzyme will have boundsubstrate under these conditions?