Based on the results of Siegel $(1982),$ if I have a particularly strong history of using a particular drug $($e$.$g$.,$ heroin$)$ in a certain environment, then using that drug in a novel environment could:

Decrease the effectiveness of that drug

Cause the drug not to work $($i$.$e$.,$ it does not produce a "high"$)$

Lead to overdose because my body does not have contextual cues to process the drug

Increase the effectiveness of that drug without any potential side effects