1. Between December 2020 and April 2021, researchers in Israel conducted a study to evaluate the association between the receipt of BNT162b2 messenger RNA vaccine and risk of SARS-CoV-2 infection among pregnant women. 7530 pregnant women vaccinated with a first dose were 1:1 matched to 7530 unvaccinated women. Over the course of the study, there were 118 SARS-CoV-2 infections in the vaccinated group and 202 in the unvaccinated group. Using a 0.05 significance level, you need to test the claim that the proportion of SARS-CoV-2 infection among vaccinated pregnant women is lower than the proportion of infection in unvaccinated pregnant women. What is the value of the test statistic you should use to test the given hypothesis?

1. -3.23
2. -4.47
3. -6.69
4. -4.75
5. -3.37