BIOCHEMISTRY QUESTION

PLEASE ANSWER #1 and #2. Thanks!!

1. (1 pt) The acyl-CoA synthetase reaction (shown below) is readily reversible (Keq1) in a test tube. However, in a cell is it metabolically favored to produce fatty acyl-CoA (G0). Using what you know from glycogen metabolism, describe in chemical details why G0 for this reaction. Palmitate+ATP+COAPalmitoyl-COA+AMP+PPi 2. (1 pt) In the condensation reaction catalyzed by -ketoacyl-ACP synthase (reaction shown below), a four-carbon unit is synthesized by the combination of a two-carbon unit (equivalent of Acetyl-CoA) and a three-carbon unit (equivalent of malonyl-CoA), with the release of CO2. What is the thermodynamic advantage of this process over one that simply combines 2 twocarbon units (equivalent of 2 Acetyl-CoA)? malonyl-ACPacctyl-KSBKatobuty,yACP