Biomedical Engineering, Goldman's Equation

Steady state concentrations and permeabilities are given for a membrane. Note that A+is not permeable. The ion channel resistances are RK=1.7k,RNa=9.09K,RCl=3.125K Ke+=6mMKi+=168mMPk=1Nqe+=337mMNai+=50mMPNa+=0.019Cle=340mMCl=41mMPcl=0.3810 F=96487C/gram equivalent, R=8.314J/K mole at 27C,T=27C a) Compute the resting membrane potential, Vm by using Goldmen's Equation and comment on ion movements in total and for each ion. b) Find therenin equivolent circuit as the figure below. c) Design a current stimulus that will drive vm to threshold at t0=2ms. When Cm=1F, and the threshold potential is 40mV, find the current pulse magnitude (K) as the figure above. Sketch vm and Ic roughly according to the current source Is. d) What is the condition to initiate a new action petential after applying this current source in part (c)