Bs 11 Few successful business owners find perfect formulas straight out of the gate. On the contrary: ideas must morph over time. Whether tweaking product design or altering food items on a menu, finding the perfect sweet spot takes trial and error.

11 Please explain why the incidence of ovarian cancer (surface epithelial type)/carcinoma is low in women who take the oral contraceptive pill and who have undergone tubal ligation, compared with the general population?

12 What is the treatment of Kaposi's sarcoma?

13 How effective is a paracetamol and codeine phosphate combination in cancer pain therapy and ordinary pain therapy, and what is the difference in using them in cancer pain therapy?

14 What is meant by co-analgesic drugs in palliative care?

15 Is trastuzumab useful in all patients with metastatic breast cancer?

16 I have heard that Imatinib is useful in stromal cell tumours. Can you explain the mechanism?

17 Does monoclonal gammopathy of unknown significance (MGUS) progress to multiple myeloma?

18 Why do some cancers particularly metastase to bone?

19 What is the difference between lead time bias and length time bias.

20 Could lymphocytosis (lymphocytes: 4.4 109 /L, representing 56% of total lymphocytic count) and not accompanied by any other haematological or systemic symptoms or signs except for mild weight loss (5-10% previous body weight) some 12 years ago, with no progression until now, be chronic lymphocytic leukaemia?