By 1 week after the ED visit, patients randomized to ibuprofen plus placebo reported a mean ( SD) improvement in the RMDQ of 11.9 ( 9.7), while those randomized to ibuprofen plus acetaminophen reported a mean ( SD) improvement of 11.1 ( 10.7). The 95% CI for the between-group difference of 0.8 was 3.0 to 4.7. At the 1-week follow-up, slightly more than 25% of both study groups reported moderate or severe pain.

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